Bone grafting surgery is one of the most commonly performed procedures in the Orthopaedic, Dental, Maxillofacial, and Neurosurgery. It is the second most performed transplantation; it comes just after blood transfusion.
A bone graft material is defined as any implanted material that, alone or in combination with other materials, promotes a bone healing response by providing osteogenic, osteoconductive or osteoinductive activity to a local site. The gold standard for bone grafting is autologous bone graft which is obtained from the patient's own body and consists of harvesting cancellous bone, most often from the iliac crest, in order to replace lost bone. Though ideal, autologous bone grafting carries morbidity risks to the donor and other risks such as fracture chronic pain, blood loss, deformity, donor site instability and an additional scar. The amount of grafting material is also often insufficient. Presently, there is a large number of materials available for the repair and reconstruction of skeletal defects such as autogenous, allogenous, xenogenous bone graft and alloplastic or synthetic bone graft.
Among synthetic bone grafts, calcium phosphate (CaP) biomaterials are one of the most common and successful due to their similar composition to the inorganic phase of the bone tissue [1]. The CaP bioceramics may include hydroxyapatite (HA) Ca10(PO4)6(OH)2, beta-tricalcium phosphate (β-TCP) Ca3(PO4)2, , or a combination in a wide variety of ratios of these two phases into a single product known as biphasic calcium phosphate (BCP). Hydroxyapatite is able to promote apatite precipitation at its surface immediately after implantation, which gives it bone bonding properties. However HA has a low resorption rate, so it has to be mixed with β-TCP that is characterized, in contrast, by a higher solubility and a rapid degradation/resorption rate. This gives a tuning property to the BCP formulations to modulate the resorption rate and the bioactivity of the bioceramics.
CaP bioceramics have a long safety history record, they have been shown to be non-toxic, non-inflammatory, biocompatible and osteoconductive in both animals and humans. The BCP family of CaPs with a wide range of HA/β-TCP phase ratios, in particular, achieved remarkable clinical success and has been reported to trend toward being a gold standard of synthetic bone grafting material [2].
Our products include a new generation of orthobiologic ultrapure bioceramics with an enhanced bioactivity, excellent osteoconduction, controlled and highly interconnected multi-scale porosity and a nanostructured surface for good cell attachment.
Our bioceramics can be supplied in different shapes and forms, such as:
[1] W. Habraken, P. Habibovic, M. Epple, M. Bohner, Calcium phosphates in biomedical applications: materials for the future? Mater. Today 19 (2016) 69e87.
[2] Bouler et al Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response, Acta Biomaterialia 53 (2017) 1–12
For More information please contact us: info@biomatcan.com
A bone graft material is defined as any implanted material that, alone or in combination with other materials, promotes a bone healing response by providing osteogenic, osteoconductive or osteoinductive activity to a local site. The gold standard for bone grafting is autologous bone graft which is obtained from the patient's own body and consists of harvesting cancellous bone, most often from the iliac crest, in order to replace lost bone. Though ideal, autologous bone grafting carries morbidity risks to the donor and other risks such as fracture chronic pain, blood loss, deformity, donor site instability and an additional scar. The amount of grafting material is also often insufficient. Presently, there is a large number of materials available for the repair and reconstruction of skeletal defects such as autogenous, allogenous, xenogenous bone graft and alloplastic or synthetic bone graft.
Among synthetic bone grafts, calcium phosphate (CaP) biomaterials are one of the most common and successful due to their similar composition to the inorganic phase of the bone tissue [1]. The CaP bioceramics may include hydroxyapatite (HA) Ca10(PO4)6(OH)2, beta-tricalcium phosphate (β-TCP) Ca3(PO4)2, , or a combination in a wide variety of ratios of these two phases into a single product known as biphasic calcium phosphate (BCP). Hydroxyapatite is able to promote apatite precipitation at its surface immediately after implantation, which gives it bone bonding properties. However HA has a low resorption rate, so it has to be mixed with β-TCP that is characterized, in contrast, by a higher solubility and a rapid degradation/resorption rate. This gives a tuning property to the BCP formulations to modulate the resorption rate and the bioactivity of the bioceramics.
CaP bioceramics have a long safety history record, they have been shown to be non-toxic, non-inflammatory, biocompatible and osteoconductive in both animals and humans. The BCP family of CaPs with a wide range of HA/β-TCP phase ratios, in particular, achieved remarkable clinical success and has been reported to trend toward being a gold standard of synthetic bone grafting material [2].
Our products include a new generation of orthobiologic ultrapure bioceramics with an enhanced bioactivity, excellent osteoconduction, controlled and highly interconnected multi-scale porosity and a nanostructured surface for good cell attachment.
Our bioceramics can be supplied in different shapes and forms, such as:
- Powders
- Granules
- Blocs
- Porous shapes
- Settable pastes and putties
[1] W. Habraken, P. Habibovic, M. Epple, M. Bohner, Calcium phosphates in biomedical applications: materials for the future? Mater. Today 19 (2016) 69e87.
[2] Bouler et al Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response, Acta Biomaterialia 53 (2017) 1–12
For More information please contact us: info@biomatcan.com
Products Highlights
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Highest purity Our bioceramics contain the lowest level of impurities which promotes better biocompatibility and faster bone healing. Bioactive Our products encourage a very quick bioactive response. Osteoconductive & Controlled Microstructure Our bioceramics' porous macro-, micro- and nano-structure is controlled to yield a superior bone regeneration compared to competitive products in the market. The engineered microstructure greatly enhance implant stability and integration with the host bone. . Balanced formulation Our unique biphasic formulation (50%HA/50%Beta-TCP) promotes an optimal bioactivity balance between the bioresorption/remodelling process, best supported by beta-TCP, and the long term stability of the 3D scaffold, best supported by HA. This balance is critical to the bone regeneration/healing process. Safe Fully Synthetic Biomaterials with no risk of Biological contamination. And More...... |
High Hydrophilicity and Capillary forces provide implant stability and enhance osteointegration
(Similar device take almost 2 min) |
